Cargando…

SAAFEC-SEQ: A Sequence-Based Method for Predicting the Effect of Single Point Mutations on Protein Thermodynamic Stability

Modeling the effect of mutations on protein thermodynamics stability is useful for protein engineering and understanding molecular mechanisms of disease-causing variants. Here, we report a new development of the SAAFEC method, the SAAFEC-SEQ, which is a gradient boosting decision tree machine learni...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Gen, Panday, Shailesh Kumar, Alexov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827184/
https://www.ncbi.nlm.nih.gov/pubmed/33435356
http://dx.doi.org/10.3390/ijms22020606