Inhibition of InsP3R with Xestospongin B Reduces Mitochondrial Respiration and Induces Selective Cell Death in T Cell Acute Lymphoblastic Leukemia Cells

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy whose chemoresistance and relapse persist as a problem despite significant advances in its chemotherapeutic treatments. Mitochondrial metabolism has emerged as an interesting therapeutic target given its essential...

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Detalles Bibliográficos
Autores principales: Cruz, Pablo, Ahumada-Castro, Ulises, Bustos, Galdo, Molgó, Jordi, Sauma, Daniela, Lovy, Alenka, Cárdenas, César
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827595/
https://www.ncbi.nlm.nih.gov/pubmed/33440859
http://dx.doi.org/10.3390/ijms22020651

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827595/
https://www.ncbi.nlm.nih.gov/pubmed/33440859
http://dx.doi.org/10.3390/ijms22020651

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