Effect of Microbial Short-Chain Fatty Acids on CYP3A4-Mediated Metabolic Activation of Human Pluripotent Stem Cell-Derived Liver Organoids

The early and accurate prediction of the hepatotoxicity of new drug targets during nonclinical drug development is important to avoid postmarketing drug withdrawals and late-stage failures. We previously established long-term expandable and functional human-induced pluripotent stem cell (iPSC)-deriv...

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Detalles Bibliográficos
Autores principales: Mun, Seon Ju, Lee, Jaeseo, Chung, Kyung-Sook, Son, Mi-Young, Son, Myung Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827634/
https://www.ncbi.nlm.nih.gov/pubmed/33440728
http://dx.doi.org/10.3390/cells10010126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827634/
https://www.ncbi.nlm.nih.gov/pubmed/33440728
http://dx.doi.org/10.3390/cells10010126

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