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Effect of Microbial Short-Chain Fatty Acids on CYP3A4-Mediated Metabolic Activation of Human Pluripotent Stem Cell-Derived Liver Organoids

The early and accurate prediction of the hepatotoxicity of new drug targets during nonclinical drug development is important to avoid postmarketing drug withdrawals and late-stage failures. We previously established long-term expandable and functional human-induced pluripotent stem cell (iPSC)-deriv...

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Detalles Bibliográficos
Autores principales:	Mun, Seon Ju, Lee, Jaeseo, Chung, Kyung-Sook, Son, Mi-Young, Son, Myung Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827634/ https://www.ncbi.nlm.nih.gov/pubmed/33440728 http://dx.doi.org/10.3390/cells10010126

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