Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by si...

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Detalles Bibliográficos
Autores principales: Németh, András Gy., Szabó, Renáta, Orsy, György, Mándity, István M., Keserű, György M., Ábrányi-Balogh, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827778/
https://www.ncbi.nlm.nih.gov/pubmed/33435580
http://dx.doi.org/10.3390/molecules26020303
Descripción
Sumario:We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

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