Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by si...

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Autores principales: Németh, András Gy., Szabó, Renáta, Orsy, György, Mándity, István M., Keserű, György M., Ábrányi-Balogh, Péter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827778/
https://www.ncbi.nlm.nih.gov/pubmed/33435580
http://dx.doi.org/10.3390/molecules26020303
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author Németh, András Gy.
Szabó, Renáta
Orsy, György
Mándity, István M.
Keserű, György M.
Ábrányi-Balogh, Péter
author_facet Németh, András Gy.
Szabó, Renáta
Orsy, György
Mándity, István M.
Keserű, György M.
Ábrányi-Balogh, Péter
author_sort Németh, András Gy.
collection PubMed
description We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.
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spelling pubmed-78277782021-01-25 Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution Németh, András Gy. Szabó, Renáta Orsy, György Mándity, István M. Keserű, György M. Ábrányi-Balogh, Péter Molecules Article We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur. MDPI 2021-01-08 /pmc/articles/PMC7827778/ /pubmed/33435580 http://dx.doi.org/10.3390/molecules26020303 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Németh, András Gy.
Szabó, Renáta
Orsy, György
Mándity, István M.
Keserű, György M.
Ábrányi-Balogh, Péter
Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
title Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
title_full Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
title_fullStr Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
title_full_unstemmed Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
title_short Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution
title_sort continuous-flow synthesis of thioureas, enabled by aqueous polysulfide solution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827778/
https://www.ncbi.nlm.nih.gov/pubmed/33435580
http://dx.doi.org/10.3390/molecules26020303
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