The Inhibition of CDK8/19 Mediator Kinases Prevents the Development of Resistance to EGFR-Targeting Drugs

Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequency than mutations and may involve population-scale...

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Detalles Bibliográficos
Autores principales: Sharko, Amanda C., Lim, Chang-Uk, McDermott, Martina S. J., Hennes, Chuck, Philavong, Kingsavanh P., Aiken, Tiffanie, Tatarskiy, Victor V., Roninson, Igor B., Broude, Eugenia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828184/
https://www.ncbi.nlm.nih.gov/pubmed/33445730
http://dx.doi.org/10.3390/cells10010144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828184/
https://www.ncbi.nlm.nih.gov/pubmed/33445730
http://dx.doi.org/10.3390/cells10010144

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