Mechanical Loading-Driven Tumor Suppression Is Mediated by Lrp5-Dependent and Independent Mechanisms

SIMPLE SUMMARY: Advanced breast cancer and prostate cancer metastasize to varying organs including the bone. We show here that mechanical loading to the knee suppresses tumor growth in the loaded bone and the non-loaded mammary pad. Although lipoprotein receptor-related protein 5 (Lrp5) in osteocyte...

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Detalles Bibliográficos
Autores principales: Feng, Yan, Liu, Shengzhi, Zha, Rongrong, Sun, Xun, Li, Kexin, Robling, Alexander, Li, Baiyan, Yokota, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828232/
https://www.ncbi.nlm.nih.gov/pubmed/33450808
http://dx.doi.org/10.3390/cancers13020267

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828232/
https://www.ncbi.nlm.nih.gov/pubmed/33450808
http://dx.doi.org/10.3390/cancers13020267

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