Cargando…
Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling
IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of e...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828256/ https://www.ncbi.nlm.nih.gov/pubmed/33635005 http://dx.doi.org/10.1002/ctm2.278 |
| _version_ | 1783640967366049792 |
|---|---|
| author | Sorrentino, Carlo Ciummo, Stefania Livia D'Antonio, Luigi Lanuti, Paola Abrams, Scott I. Yin, Zhinan Lu, Li‐Fan Di Carlo, Emma |
| author_facet | Sorrentino, Carlo Ciummo, Stefania Livia D'Antonio, Luigi Lanuti, Paola Abrams, Scott I. Yin, Zhinan Lu, Li‐Fan Di Carlo, Emma |
| author_sort | Sorrentino, Carlo |
| collection | PubMed |
| description | IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells. [Image: see text] |
| format | Online Article Text |
| id | pubmed-7828256 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-78282562021-02-01 Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling Sorrentino, Carlo Ciummo, Stefania Livia D'Antonio, Luigi Lanuti, Paola Abrams, Scott I. Yin, Zhinan Lu, Li‐Fan Di Carlo, Emma Clin Transl Med Letter to Editor IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of endogenous IL30, requires INFγ production by T and NK cells. [Image: see text] John Wiley and Sons Inc. 2021-01-24 /pmc/articles/PMC7828256/ /pubmed/33635005 http://dx.doi.org/10.1002/ctm2.278 Text en © 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Letter to Editor Sorrentino, Carlo Ciummo, Stefania Livia D'Antonio, Luigi Lanuti, Paola Abrams, Scott I. Yin, Zhinan Lu, Li‐Fan Di Carlo, Emma Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling |
| title | Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling |
| title_full | Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling |
| title_fullStr | Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling |
| title_full_unstemmed | Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling |
| title_short | Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling |
| title_sort | hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires ifnγ signaling |
| topic | Letter to Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828256/ https://www.ncbi.nlm.nih.gov/pubmed/33635005 http://dx.doi.org/10.1002/ctm2.278 |
| work_keys_str_mv | AT sorrentinocarlo hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT ciummostefanialivia hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT dantonioluigi hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT lanutipaola hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT abramsscotti hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT yinzhinan hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT lulifan hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling AT dicarloemma hinderingtriplenegativebreastcancerprogressionbytargetingendogenousinterleukin30requiresifngsignaling |