Cargando…
Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNγ signaling
IL30mRNA expression is associated with the TNBC subtype. IL30 boosts proliferation and migration of TNBC cells and reshapes their immunity gene expression profile. The lack of endogenous IL30 hinders TNBC growth and progression and prolongs host survival. TNBC growth inhibition, due to the lack of e...
Autores principales: | Sorrentino, Carlo, Ciummo, Stefania Livia, D'Antonio, Luigi, Lanuti, Paola, Abrams, Scott I., Yin, Zhinan, Lu, Li‐Fan, Di Carlo, Emma |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828256/ https://www.ncbi.nlm.nih.gov/pubmed/33635005 http://dx.doi.org/10.1002/ctm2.278 |
Ejemplares similares
-
Interleukin-30 feeds breast cancer stem cells via CXCL10 and IL23 autocrine loops and shapes immune contexture and host outcome
por: Sorrentino, Carlo, et al.
Publicado: (2021) -
Inactivation of interleukin-30 in colon cancer stem cells via CRISPR/Cas9 genome editing inhibits their oncogenicity and improves host survival
por: D'Antonio, Luigi, et al.
Publicado: (2023) -
Targeting Interleukin(IL)-30/IL-27p28 signaling in cancer stem-like cells and host environment synergistically inhibits prostate cancer growth and improves survival
por: Sorrentino, Carlo, et al.
Publicado: (2019) -
CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality
por: Sorrentino, Carlo, et al.
Publicado: (2022) -
The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs
por: Ciummo, Stefania Livia, et al.
Publicado: (2021)