Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes. This reduction of heterozygosity creates genetic differences between tumor and normal ce...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaonan, Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828287/
https://www.ncbi.nlm.nih.gov/pubmed/33450833
http://dx.doi.org/10.3390/ph14010057

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828287/
https://www.ncbi.nlm.nih.gov/pubmed/33450833
http://dx.doi.org/10.3390/ph14010057

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