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Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy
Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes. This reduction of heterozygosity creates genetic differences between tumor and normal ce...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828287/ https://www.ncbi.nlm.nih.gov/pubmed/33450833 http://dx.doi.org/10.3390/ph14010057 |