Identification of DNA Methyltransferase-1 Inhibitor for Breast Cancer Therapy through Computational Fragment-Based Drug Design

Epimutation by DNA Methyltransferase 1 (DNMT1), an epigenetic regulator enzyme, may lead to the proliferation of breast cancer. In this report, 168,686 natural products from the PubChem database were screened and modified by in silico method to acquire the potential inhibitor of DNMT1. The initial s...

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Detalles Bibliográficos
Autores principales: Alkaff, Ahmad Husein, Saragih, Mutiara, Imana, Shabrina Noor, Nasution, Mochammad Arfin Fardiansyah, Tambunan, Usman Sumo Friend
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828308/
https://www.ncbi.nlm.nih.gov/pubmed/33450856
http://dx.doi.org/10.3390/molecules26020375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828308/
https://www.ncbi.nlm.nih.gov/pubmed/33450856
http://dx.doi.org/10.3390/molecules26020375

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