Specificity of Molecular Fragments Binding to S100B versus S100A1 as Identified by NMR and Site Identification by Ligand Competitive Saturation (SILCS)

S100B, a biomarker of malignant melanoma, interacts with the p53 protein and diminishes its tumor suppressor function, which makes this S100 family member a promising therapeutic target for treating malignant melanoma. However, it is a challenge to design inhibitors that are specific for S100B in me...

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Detalles Bibliográficos
Autores principales: Young, Brianna D., Yu, Wenbo, Rodríguez, Darex J. Vera, Varney, Kristen M., MacKerell, Alexander D., Weber, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828390/
https://www.ncbi.nlm.nih.gov/pubmed/33450915
http://dx.doi.org/10.3390/molecules26020381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828390/
https://www.ncbi.nlm.nih.gov/pubmed/33450915
http://dx.doi.org/10.3390/molecules26020381

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