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Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease
The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 150 different membrane protein substrates. Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid β-protein (Aβ)...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828430/ https://www.ncbi.nlm.nih.gov/pubmed/33450968 http://dx.doi.org/10.3390/molecules26020388 |