Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase, taking part in the activation pathway of the pro-inflammatory transcription factor NF-kB and is demonstrating a therapeutic target potential in inflammatory diseases such as asthma, psoriasis and atherosclerosis. To date, few MSK1 in...

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Detalles Bibliográficos
Autores principales: Bollenbach, Maud, Nemska, Simona, Wagner, Patrick, Camelin, Guillaume, Daubeuf, François, Obrecht, Adeline, Villa, Pascal, Rognan, Didier, Bihel, Frédéric, Bourguignon, Jean-Jacques, Schmitt, Martine, Frossard, Nelly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828447/
https://www.ncbi.nlm.nih.gov/pubmed/33450992
http://dx.doi.org/10.3390/molecules26020391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828447/
https://www.ncbi.nlm.nih.gov/pubmed/33450992
http://dx.doi.org/10.3390/molecules26020391

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