FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells

Cancer initiating cells (CICs) drive tumor formation and drug-resistance, but how they develop drug-resistance characteristics is not well understood. In this study, we demonstrate that chemotherapeutic agent FOLFOX, commonly used for drug-resistant/metastatic colorectal cancer (CRC) treatment, indu...

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Detalles Bibliográficos
Autores principales: Ghatak, Shibnath, Hascall, Vincent C., Markwald, Roger R., Misra, Suniti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828641/
https://www.ncbi.nlm.nih.gov/pubmed/33451103
http://dx.doi.org/10.3390/ijms22020753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828641/
https://www.ncbi.nlm.nih.gov/pubmed/33451103
http://dx.doi.org/10.3390/ijms22020753

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