Amorphous Solid Dispersions and the Contribution of Nanoparticles to In Vitro Dissolution and In Vivo Testing: Niclosamide as a Case Study

We developed an amorphous solid dispersion (ASD) of the poorly water-soluble molecule niclosamide that achieved a more than two-fold increase in bioavailability. Notably, this niclosamide ASD formulation increased the apparent drug solubility about 60-fold relative to the crystalline material due to...

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Detalles Bibliográficos
Autores principales: Jara, Miguel O., Warnken, Zachary N., Williams, Robert O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828663/
https://www.ncbi.nlm.nih.gov/pubmed/33466598
http://dx.doi.org/10.3390/pharmaceutics13010097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828663/
https://www.ncbi.nlm.nih.gov/pubmed/33466598
http://dx.doi.org/10.3390/pharmaceutics13010097

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