Nuclear Pore Complexes Cluster in Dysmorphic Nuclei of Normal and Progeria Cells during Replicative Senescence

Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease caused by a mutation in LMNA. A G608G mutation in exon 11 of LMNA is responsible for most HGPS cases, generating a truncated protein called “progerin”. Progerin is permanently farnesylated and accumulates in HGPS cells, ca...

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Detalles Bibliográficos
Autores principales: Röhrl, Jennifer M., Arnold, Rouven, Djabali, Karima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828780/
https://www.ncbi.nlm.nih.gov/pubmed/33466669
http://dx.doi.org/10.3390/cells10010153

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7828780/
https://www.ncbi.nlm.nih.gov/pubmed/33466669
http://dx.doi.org/10.3390/cells10010153

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