Complement-Dependent Activity of CD20-Specific IgG Correlates With Bivalent Antigen Binding and C1q Binding Strength

Monoclonal antibodies directed against the CD20 surface antigen on B cells are widely used in the therapy of B cell malignancies. Upon administration, the antibodies bind to CD20 expressing B cells and induce their depletion via cell- and complement-dependent cytotoxicity or by induction of direct c...

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Detalles Bibliográficos
Autores principales: Bondza, Sina, Marosan, Anita, Kara, Sibel, Lösing, Josephine, Peipp, Matthias, Nimmerjahn, Falk, Buijs, Jos, Lux, Anja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829346/
https://www.ncbi.nlm.nih.gov/pubmed/33505398
http://dx.doi.org/10.3389/fimmu.2020.609941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829346/
https://www.ncbi.nlm.nih.gov/pubmed/33505398
http://dx.doi.org/10.3389/fimmu.2020.609941

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