Optimization of 1,4-Naphthoquinone Hit Compound: A Computational, Phenotypic, and In Vivo Screening against Trypanosoma cruzi

Chagas disease (CD) still represents a serious public health problem in Latin America, even after more than 100 years of its discovery. Clinical treatments (nifurtimox and benznidazole) are considered inadequate, especially because of undesirable side effects and low efficacy in the chronic stages o...

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Detalles Bibliográficos
Autores principales: Lara, Leonardo S., Lechuga, Guilherme C., Moreira, Caroline dos S., Santos, Thaís B., Ferreira, Vitor F., da Rocha, David R., Pereira, Mirian C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829778/
https://www.ncbi.nlm.nih.gov/pubmed/33467422
http://dx.doi.org/10.3390/molecules26020423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829778/
https://www.ncbi.nlm.nih.gov/pubmed/33467422
http://dx.doi.org/10.3390/molecules26020423

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