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Therapeutic Targeting of Autoreactive B Cells: Why, How, and When?

B lymphocytes play critical roles in the development of autoimmunity, acting as autoantibody manufacturers, antigen-presenting cells, and producers of cytokines. Pan-B cell depletion has demonstrated efficacy in treatment of many autoimmune disorders, but carries with it an unfavorable safety profil...

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Detalles Bibliográficos
Autores principales: Stensland, Zachary C., Cambier, John C., Smith, Mia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829839/
https://www.ncbi.nlm.nih.gov/pubmed/33467130
http://dx.doi.org/10.3390/biomedicines9010083