Development and Validation of a Bioanalytical LC-MS/MS Method for Simultaneous Determination of Sirolimus in Porcine Whole Blood and Lung Tissue and Pharmacokinetic Application with Coronary Stents

Sirolimus is a hydrophobic macrolide compound that has been used for long-term immunosuppressive therapy, prevention of restenosis, and treatment of lymphangioleiomyomatosis. In this study, a simple and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated f...

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Detalles Bibliográficos
Autores principales: Nguyen, Thi-Thao-Linh, Duong, Van-An, Vo, Dang-Khoa, Jo, Jeongae, Maeng, Han-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829871/
https://www.ncbi.nlm.nih.gov/pubmed/33467464
http://dx.doi.org/10.3390/molecules26020425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829871/
https://www.ncbi.nlm.nih.gov/pubmed/33467464
http://dx.doi.org/10.3390/molecules26020425

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