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Empagliflozin Attenuates Non-Alcoholic Fatty Liver Disease (NAFLD) in High Fat Diet Fed ApoE((-/-)) Mice by Activating Autophagy and Reducing ER Stress and Apoptosis
Aims/hypothesis: SGLT-2 inhibitors (SGLT-2i) have been studied as potential treatments against NAFLD, showing varying beneficial effects. The molecular mechanisms mediating these effects have not been fully clarified. Herein, we investigated the impact of empagliflozin on NAFLD, focusing particularl...
Autores principales: | Nasiri-Ansari, Narjes, Nikolopoulou, Chrysa, Papoutsi, Katerina, Kyrou, Ioannis, Mantzoros, Christos S., Kyriakopoulos, Georgios, Chatzigeorgiou, Antonios, Kalotychou, Vassiliki, Randeva, Manpal S., Chatha, Kamaljit, Kontzoglou, Konstantinos, Kaltsas, Gregory, Papavassiliou, Athanasios G., Randeva, Harpal S., Kassi, Eva |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7829901/ https://www.ncbi.nlm.nih.gov/pubmed/33467546 http://dx.doi.org/10.3390/ijms22020818 |
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