Overcoming Hypoxia-Induced Chemoresistance in Cancer Using a Novel Glycoconjugate of Methotrexate

The oxygen and nutrient-deprived tumor microenvironment is considered a key mechanism responsible for cancer resistance to chemotherapy. Methotrexate (MTX) is a widely incorporated chemotherapeutic agent employed in the treatment of several malignancies. However, drug resistance and systemic toxicit...

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Detalles Bibliográficos
Autores principales: Woźniak, Marta, Pastuch-Gawołek, Gabriela, Makuch, Sebastian, Wiśniewski, Jerzy, Ziółkowski, Piotr, Szeja, Wiesław, Krawczyk, Monika, Agrawal, Siddarth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830245/
https://www.ncbi.nlm.nih.gov/pubmed/33374474
http://dx.doi.org/10.3390/ph14010013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830245/
https://www.ncbi.nlm.nih.gov/pubmed/33374474
http://dx.doi.org/10.3390/ph14010013

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