Colistimethate Acidic Hydrolysis Revisited: Arrhenius Equation Modeling Using UPLC-QToF MS

Colistimethate (CMS), the prodrug of polymyxin E (colistin), is an antibiotic widely used as a last-line therapy against multidrug resistant Gram-negative bacteria, but little is known about its pharmacokinetics as its administration has stopped as a result of high neuro- and nephro-toxicity. The me...

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Detalles Bibliográficos
Autores principales: Dagla, Ioanna, Tsarbopoulos, Anthony, Gikas, Evagelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830259/
https://www.ncbi.nlm.nih.gov/pubmed/33467022
http://dx.doi.org/10.3390/molecules26020447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830259/
https://www.ncbi.nlm.nih.gov/pubmed/33467022
http://dx.doi.org/10.3390/molecules26020447

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