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Colistimethate Acidic Hydrolysis Revisited: Arrhenius Equation Modeling Using UPLC-QToF MS

Colistimethate (CMS), the prodrug of polymyxin E (colistin), is an antibiotic widely used as a last-line therapy against multidrug resistant Gram-negative bacteria, but little is known about its pharmacokinetics as its administration has stopped as a result of high neuro- and nephro-toxicity. The me...

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Detalles Bibliográficos
Autores principales:	Dagla, Ioanna, Tsarbopoulos, Anthony, Gikas, Evagelos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830259/ https://www.ncbi.nlm.nih.gov/pubmed/33467022 http://dx.doi.org/10.3390/molecules26020447

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