A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights

Background: Cyclin-dependent kinases (CDKs) regulate mammalian cell cycle progression and RNA transcription. Based on the structural analysis of previously reported CDK2 inhibitors, a new compound with 3-hydrazonoindolin-2-one scaffold (HI 5) was well designed, synthesized, and biologically evaluate...

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Detalles Bibliográficos
Autores principales: Al-Sanea, Mohammad M., Obaidullah, Ahmad J., Shaker, Mohamed E., Chilingaryan, Garri, Alanazi, Mohammed M., Alsaif, Nawaf A., Alkahtani, Hamad M., Alsubaie, Sultan A., Abdelgawad, Mohamed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830330/
https://www.ncbi.nlm.nih.gov/pubmed/33466812
http://dx.doi.org/10.3390/molecules26020412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830330/
https://www.ncbi.nlm.nih.gov/pubmed/33466812
http://dx.doi.org/10.3390/molecules26020412

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