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Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study

A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat wer...

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Autores principales: de Camargo, Adriano Costa, de Souza Silva, Anna Paula, Soares, Jackeline Cintra, de Alencar, Severino Matias, Handa, Cíntia Ladeira, Cordeiro, Karina Silva, Figueira, Marcela Souza, Sampaio, Geni R., Torres, Elizabeth A. F. S., Shahidi, Fereidoon, Schwember, Andrés R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830396/
https://www.ncbi.nlm.nih.gov/pubmed/33477281
http://dx.doi.org/10.3390/molecules26020463
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author de Camargo, Adriano Costa
de Souza Silva, Anna Paula
Soares, Jackeline Cintra
de Alencar, Severino Matias
Handa, Cíntia Ladeira
Cordeiro, Karina Silva
Figueira, Marcela Souza
Sampaio, Geni R.
Torres, Elizabeth A. F. S.
Shahidi, Fereidoon
Schwember, Andrés R.
author_facet de Camargo, Adriano Costa
de Souza Silva, Anna Paula
Soares, Jackeline Cintra
de Alencar, Severino Matias
Handa, Cíntia Ladeira
Cordeiro, Karina Silva
Figueira, Marcela Souza
Sampaio, Geni R.
Torres, Elizabeth A. F. S.
Shahidi, Fereidoon
Schwember, Andrés R.
author_sort de Camargo, Adriano Costa
collection PubMed
description A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat were evaluated in this contribution. The highest recovery of phenolics was achieved using aqueous acetone (50:50, v/v), as verified by multi-response optimization, thus showing that phenolics could be largely underestimated by employing an inappropriate extraction. The concentration of derivatives of apigenin, the main phenolics present, ranged from 63.5 to 80.7%, as evaluated by LC–ESI-QTOF-MS. Phenolics from the breeding line 98 exhibited the highest ability in scavenging peroxyl radicals, reducing power as well as in terms of inhibition of pancreatic lipase activity, a key enzyme regulating the absorption of triacylglycerols. In contrast, none of the samples exhibited a significant anti-diabetic potential. Despite their high concentration compared to that of phenolic acids, results of this work do not support a significant antioxidant and pancreatic lipase inhibitory effect of durum wheat flavonoids. Therefore, breeding programs and animal and/or human trials related to the effect of durum wheat flavonoids on oxidative stress and absorption of triacylglycerols are discouraged at this point.
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spelling pubmed-78303962021-01-26 Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study de Camargo, Adriano Costa de Souza Silva, Anna Paula Soares, Jackeline Cintra de Alencar, Severino Matias Handa, Cíntia Ladeira Cordeiro, Karina Silva Figueira, Marcela Souza Sampaio, Geni R. Torres, Elizabeth A. F. S. Shahidi, Fereidoon Schwember, Andrés R. Molecules Article A clear gap with respect to the potential biological properties of wheat flavonoids exists in the available literature. This information is crucial for breeding programs aiming to produce new varieties presenting improved health benefits. Accordingly, advanced breeding lines of whole durum wheat were evaluated in this contribution. The highest recovery of phenolics was achieved using aqueous acetone (50:50, v/v), as verified by multi-response optimization, thus showing that phenolics could be largely underestimated by employing an inappropriate extraction. The concentration of derivatives of apigenin, the main phenolics present, ranged from 63.5 to 80.7%, as evaluated by LC–ESI-QTOF-MS. Phenolics from the breeding line 98 exhibited the highest ability in scavenging peroxyl radicals, reducing power as well as in terms of inhibition of pancreatic lipase activity, a key enzyme regulating the absorption of triacylglycerols. In contrast, none of the samples exhibited a significant anti-diabetic potential. Despite their high concentration compared to that of phenolic acids, results of this work do not support a significant antioxidant and pancreatic lipase inhibitory effect of durum wheat flavonoids. Therefore, breeding programs and animal and/or human trials related to the effect of durum wheat flavonoids on oxidative stress and absorption of triacylglycerols are discouraged at this point. MDPI 2021-01-17 /pmc/articles/PMC7830396/ /pubmed/33477281 http://dx.doi.org/10.3390/molecules26020463 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
de Camargo, Adriano Costa
de Souza Silva, Anna Paula
Soares, Jackeline Cintra
de Alencar, Severino Matias
Handa, Cíntia Ladeira
Cordeiro, Karina Silva
Figueira, Marcela Souza
Sampaio, Geni R.
Torres, Elizabeth A. F. S.
Shahidi, Fereidoon
Schwember, Andrés R.
Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
title Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
title_full Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
title_fullStr Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
title_full_unstemmed Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
title_short Do Flavonoids from Durum Wheat Contribute to Its Bioactive Properties? A Prospective Study
title_sort do flavonoids from durum wheat contribute to its bioactive properties? a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830396/
https://www.ncbi.nlm.nih.gov/pubmed/33477281
http://dx.doi.org/10.3390/molecules26020463
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