Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target

SIMPLE SUMMARY: By studying the role of tumor acidosis in osteosarcoma, we have identified a novel lipid signaling pathway that is selectively activated in acid-induced highly metastatic cell subpopulation. Furthermore, when combined to low-serine/glycine diet, the targeting of this acid-induced lip...

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Detalles Bibliográficos
Autores principales: Cortini, Margherita, Armirotti, Andrea, Columbaro, Marta, Longo, Dario Livio, Di Pompo, Gemma, Cannas, Elena, Maresca, Alessandra, Errani, Costantino, Longhi, Alessandra, Righi, Alberto, Carelli, Valerio, Baldini, Nicola, Avnet, Sofia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830496/
https://www.ncbi.nlm.nih.gov/pubmed/33467731
http://dx.doi.org/10.3390/cancers13020311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830496/
https://www.ncbi.nlm.nih.gov/pubmed/33467731
http://dx.doi.org/10.3390/cancers13020311

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