Cargando…

Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target

SIMPLE SUMMARY: By studying the role of tumor acidosis in osteosarcoma, we have identified a novel lipid signaling pathway that is selectively activated in acid-induced highly metastatic cell subpopulation. Furthermore, when combined to low-serine/glycine diet, the targeting of this acid-induced lip...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cortini, Margherita, Armirotti, Andrea, Columbaro, Marta, Longo, Dario Livio, Di Pompo, Gemma, Cannas, Elena, Maresca, Alessandra, Errani, Costantino, Longhi, Alessandra, Righi, Alberto, Carelli, Valerio, Baldini, Nicola, Avnet, Sofia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830496/ https://www.ncbi.nlm.nih.gov/pubmed/33467731 http://dx.doi.org/10.3390/cancers13020311

Ejemplares similares

The Release of Inflammatory Mediators from Acid-Stimulated Mesenchymal Stromal Cells Favours Tumour Invasiveness and Metastasis in Osteosarcoma
por: Avnet, Sofia, et al.
Publicado: (2021)

Acid Microenvironment in Bone Sarcomas
por: Di Pompo, Gemma, et al.
Publicado: (2021)

Curcumin-Loaded Nanoparticles Impair the Pro-Tumor Activity of Acid-Stressed MSC in an In Vitro Model of Osteosarcoma
por: Di Pompo, Gemma, et al.
Publicado: (2021)

Pre-clinical Models for Studying the Interaction Between Mesenchymal Stromal Cells and Cancer Cells and the Induction of Stemness
por: Avnet, Sofia, et al.
Publicado: (2019)

Tumor-Activated Mesenchymal Stromal Cells Promote Osteosarcoma Stemness and Migratory Potential via IL-6 Secretion
por: Cortini, Margherita, et al.
Publicado: (2016)

Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis
por: Di Pompo, Gemma, et al.
Publicado: (2021)

Contribution of Mitochondrial Activity to Doxorubicin-Resistance in Osteosarcoma Cells
por: Giacomini, Isabella, et al.
Publicado: (2023)

New Advances in the Study of Bone Tumors: A Lesson From the 3D Environment
por: Cortini, Margherita, et al.
Publicado: (2019)

Endogenous Extracellular Matrix Regulates the Response of Osteosarcoma 3D Spheroids to Doxorubicin
por: Cortini, Margherita, et al.
Publicado: (2023)

Epigenetic Regulation Mediated by Sphingolipids in Cancer
por: Bozzini, Nicolò, et al.
Publicado: (2023)

Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma
por: Di Pompo, Gemma, et al.
Publicado: (2017)

Cause and effect of microenvironmental acidosis on bone metastases
por: Avnet, Sofia, et al.
Publicado: (2019)

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance
por: Avnet, Sofia, et al.
Publicado: (2016)

3D Printing and Bioprinting to Model Bone Cancer: The Role of Materials and Nanoscale Cues in Directing Cell Behavior
por: Fischetti, Tiziana, et al.
Publicado: (2021)

The Effect of Adjuvant Chemotherapy on Localized Extraskeletal Osteosarcoma: A Systematic Review
por: Tsukamoto, Shinji, et al.
Publicado: (2022)

Radiodynamic Therapy with Acridine Orange Is an Effective Treatment for Bone Metastases
por: Di Pompo, Gemma, et al.
Publicado: (2022)

Unravelling the Effect of Citrate on the Features and Biocompatibility of Magnesium Phosphate-Based Bone Cements
por: Gelli, Rita, et al.
Publicado: (2020)

Molecular Mechanisms behind Inherited Neurodegeneration of the Optic Nerve
por: Maresca, Alessandra, et al.
Publicado: (2021)

Outcome of lung metastases due to bone giant cell tumor initially managed with observation
por: Tsukamoto, Shinji, et al.
Publicado: (2020)

FT-IR Spectral Signature of Sensitive and Multidrug-Resistant Osteosarcoma Cell-Derived Extracellular Nanovesicles
por: Perut, Francesca, et al.
Publicado: (2022)

Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
por: Bonuccelli, Gloria, et al.
Publicado: (2014)

Sphingosine kinase 1 contributes to doxorubicin resistance and glycolysis in osteosarcoma
por: Ren, Xiaojun, et al.
Publicado: (2020)

The Prognostic Value of Serum Biomarkers for Survival of Children with Osteosarcoma of the Extremities
por: Basoli, Stefano, et al.
Publicado: (2023)

Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors
por: Tsukamoto, Shinji, et al.
Publicado: (2021)

Treatment of Bone Metastasis
por: Errani, Costantino
Publicado: (2022)

Metachronous osteoblastoma of the spine and osteoid osteoma of the femur
por: Errani, Costantino, et al.
Publicado: (2015)

Unveiling the biological role of sphingosine-1-phosphate receptor modulators in inflammatory bowel diseases
por: Tourkochristou, Evanthia, et al.
Publicado: (2023)

A Randomized Study on Postrelapse Disease-Free Survival with Adjuvant Mistletoe versus Oral Etoposide in Osteosarcoma Patients
por: Longhi, Alessandra, et al.
Publicado: (2014)

The anti-osteosarcoma cell activity by the sphingosine kinase 1 inhibitor SKI-V
por: Sun, Xu, et al.
Publicado: (2022)

Sphingosine Kinase-1 Is Overexpressed and Correlates with Hypoxia in Osteosarcoma: Relationship with Clinicopathological Parameters
por: Gomez-Brouchet, Anne, et al.
Publicado: (2022)

DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
por: Maresca, Alessandra, et al.
Publicado: (2015)

Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients’ bed
por: Ferrari, Stefano, et al.
Publicado: (2013)

The Effects of Systemic and Local Acidosis on Insulin Resistance and Signaling
por: Baldini, Nicola, et al.
Publicado: (2018)

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling
por: Almeida, Sara F.F., et al.
Publicado: (2023)

Late Local Recurrence of Bone Giant Cell Tumors Associated with an Increased Risk for Malignant Transformation
por: Tsukamoto, Shinji, et al.
Publicado: (2021)

The optic nerve: A “mito-window” on mitochondrial neurodegeneration
por: Maresca, Alessandra, et al.
Publicado: (2013)

Behavioral Voluntary and Social Bioassays Enabling Identification of Complex and Sex-Dependent Pain-(-Related) Phenotypes in Rats with Bone Cancer
por: Segelcke, Daniel, et al.
Publicado: (2023)

High Dose Ifosfamide in Relapsed and Unresectable High-Grade Osteosarcoma Patients: A Retrospective Series
por: Palmerini, Emanuela, et al.
Publicado: (2020)

Feeding Stimulates Sphingosine-1-Phosphate Mobilization in Mouse Hypothalamus
por: Vozella, Valentina, et al.
Publicado: (2019)

Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
por: Wu, Yilun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_58jonp19594a2d9q7ls2qcinr5