Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and p...

Descripción completa

Detalles Bibliográficos
Autores principales: Giri, Bhupendra Raj, Kim, Jung Suk, Park, Jong Hyuck, Jin, Sung Giu, Kim, Kyeong Soo, Din, Fakhar ud, Choi, Han Gon, Kim, Dong Wuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830624/
https://www.ncbi.nlm.nih.gov/pubmed/33467157
http://dx.doi.org/10.3390/pharmaceutics13010111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830624/
https://www.ncbi.nlm.nih.gov/pubmed/33467157
http://dx.doi.org/10.3390/pharmaceutics13010111

Ejemplares similares