Lactate Limits T Cell Proliferation via the NAD(H) Redox State

Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector T cells. We report that nicotinamide adenine dinucleot...

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Detalles Bibliográficos
Autores principales: Quinn, William J., Jiao, Jing, TeSlaa, Tara, Stadanlick, Jason, Wang, Zhonglin, Wang, Liqing, Akimova, Tatiana, Angelin, Alessia, Schäfer, Patrick M., Cully, Michelle D., Perry, Caroline, Kopinski, Piotr K., Guo, Lili, Blair, Ian A., Ghanem, Louis R., Leibowitz, Michael S., Hancock, Wayne W., Moon, Edmund K., Levine, Matthew H., Eruslanov, Evgeniy B., Wallace, Douglas C., Baur, Joseph A., Beier, Ulf H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830708/
https://www.ncbi.nlm.nih.gov/pubmed/33326785
http://dx.doi.org/10.1016/j.celrep.2020.108500

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830708/
https://www.ncbi.nlm.nih.gov/pubmed/33326785
http://dx.doi.org/10.1016/j.celrep.2020.108500

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