Lithium Reduces Migration and Collagen Synthesis Activity in Human Cardiac Fibroblasts by Inhibiting Store-Operated Ca(2+) Entry

Cardiac fibrosis plays a vital role in the pathogenesis of heart failure. Fibroblast activity is enhanced by increases in store-operated Ca(2+) entry (SOCE) and calcium release-activated calcium channel protein 1 (Orai1) levels. Lithium regulates SOCE; however, whether therapeutic concentrations of...

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Detalles Bibliográficos
Autores principales: Chen, Pao-Huan, Chung, Cheng-Chih, Lin, Yuan-Feng, Kao, Yu-Hsun, Chen, Yi-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830715/
https://www.ncbi.nlm.nih.gov/pubmed/33467715
http://dx.doi.org/10.3390/ijms22020842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830715/
https://www.ncbi.nlm.nih.gov/pubmed/33467715
http://dx.doi.org/10.3390/ijms22020842

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