Multiple-Monitor HPLC Assays for Rapid Process Development, In-Process Monitoring, and Validation of AAV Production and Purification

HPLC is established as a fast convenient analytical technology for characterizing the content of empty and full capsids in purified samples containing adeno-associated virus (AAV). UV-based monitoring unfortunately over-estimates the proportion of full capsids and offers little value for characteriz...

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Detalles Bibliográficos
Autores principales: Gagnon, Pete, Goricar, Blaz, Mencin, Nina, Zvanut, Timotej, Peljhan, Sebastijan, Leskovec, Maja, Strancar, Ales
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830902/
https://www.ncbi.nlm.nih.gov/pubmed/33477351
http://dx.doi.org/10.3390/pharmaceutics13010113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830902/
https://www.ncbi.nlm.nih.gov/pubmed/33477351
http://dx.doi.org/10.3390/pharmaceutics13010113

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