Cargando…

Double Mutant Cycles as a Tool to Address Folding, Binding, and Allostery

Quantitative measurement of intramolecular and intermolecular interactions in protein structure is an elusive task, not easy to address experimentally. The phenomenon denoted ‘energetic coupling’ describes short- and long-range interactions between two residues in a protein system. A powerful method...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pagano, Livia, Toto, Angelo, Malagrinò, Francesca, Visconti, Lorenzo, Jemth, Per, Gianni, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830974/ https://www.ncbi.nlm.nih.gov/pubmed/33467625 http://dx.doi.org/10.3390/ijms22020828

Ejemplares similares

Understanding the Binding Induced Folding of Intrinsically Disordered Proteins by Protein Engineering: Caveats and Pitfalls
por: Malagrinò, Francesca, et al.
Publicado: (2020)

The kinetics of folding of the NSH2 domain from p85
por: Visconti, Lorenzo, et al.
Publicado: (2019)

Addressing the role of the α-helical extension in the folding of the third PDZ domain from PSD-95
por: Gautier, Candice, et al.
Publicado: (2017)

The Effect of Proline cis-trans Isomerization on the Folding of the C-Terminal SH2 Domain from p85
por: Troilo, Francesca, et al.
Publicado: (2019)

Determining folding and binding properties of the C‐terminal SH2 domain of SHP2
por: Nardella, Caterina, et al.
Publicado: (2021)

Understanding the Mechanism of Recognition of Gab2 by the N-SH2 Domain of SHP2
por: Visconti, Lorenzo, et al.
Publicado: (2020)

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV‐2 to the PDZ domain of the tight junction‐associated PALS1 protein
por: Toto, Angelo, et al.
Publicado: (2020)

On the Effects of Disordered Tails, Supertertiary Structure and Quinary Interactions on the Folding and Function of Protein Domains
por: Malagrinò, Francesca, et al.
Publicado: (2022)

Characterization of early and late transition states of the folding pathway of a SH2 domain
por: Toto, Angelo, et al.
Publicado: (2022)

SH2 Domains: Folding, Binding and Therapeutical Approaches
por: Diop, Awa, et al.
Publicado: (2022)

Folding and Binding Mechanisms of the SH2 Domain from Crkl
por: Nardella, Caterina, et al.
Publicado: (2022)

Unveiling the Molecular Basis of the Noonan Syndrome-Causing Mutation T42A of SHP2
por: Toto, Angelo, et al.
Publicado: (2020)

Hidden kinetic traps in multidomain folding highlight the presence of a misfolded but functionally competent intermediate
por: Gautier, Candice, et al.
Publicado: (2020)

Experimental Characterization of the Interaction between the N-Terminal SH3 Domain of Crkl and C3G
por: Pagano, Livia, et al.
Publicado: (2021)

Investigating the Molecular Basis of the Aggregation Propensity of the Pathological D76N Mutant of Beta-2 Microglobulin: Role of the Denatured State
por: Visconti, Lorenzo, et al.
Publicado: (2019)

Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains
por: Santorelli, Daniele, et al.
Publicado: (2023)

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer
por: Nardella, Caterina, et al.
Publicado: (2021)

Demonstration of Binding Induced Structural Plasticity in a SH2 Domain
por: Visconti, Lorenzo, et al.
Publicado: (2020)

Deciphering the mechanisms of binding induced folding at nearly atomic resolution: The Φ value analysis applied to IDPs
por: Gianni, Stefano, et al.
Publicado: (2014)

AlphaFold, Artificial Intelligence (AI), and Allostery
por: Nussinov, Ruth, et al.
Publicado: (2022)

Mapping the allosteric network within a SH3 domain
por: Malagrinò, Francesca, et al.
Publicado: (2019)

A structurally heterogeneous transition state underlies coupled binding and folding of disordered proteins
por: Karlsson, Elin, et al.
Publicado: (2019)

Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly
por: Gianni, Stefano, et al.
Publicado: (2021)

Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners
por: Diop, Awa, et al.
Publicado: (2023)

An intramolecular energetic network regulates ligand recognition in a SH2 domain
por: Nardella, Caterina, et al.
Publicado: (2023)

Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein
por: Toto, Angelo, et al.
Publicado: (2016)

Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain
por: Hultqvist, Greta, et al.
Publicado: (2012)

Targeting the Interaction between the SH3 Domain of Grb2 and Gab2
por: Malagrinò, Francesca, et al.
Publicado: (2020)

Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle
por: Miller, Jonathan P., et al.
Publicado: (2014)

Understanding the effect of alternative splicing in the folding and function of the second PDZ from Protein Tyrosine Phosphatase-BL
por: Di Silvio, Eva, et al.
Publicado: (2015)

MD Simulations of tRNA and Aminoacyl-tRNA Synthetases: Dynamics, Folding, Binding, and Allostery
por: Li, Rongzhong, et al.
Publicado: (2015)

Correction to “Positive Allostery in Metal Ion Binding by a Cooperatively Folded β-Peptide Bundle”
por: Miller, Jonathan P., et al.
Publicado: (2015)

The transition state structure for coupled binding and folding of disordered protein domains
por: Dogan, Jakob, et al.
Publicado: (2013)

The cooperative folding of annexin A2 relies on a transient nonnative intermediate
por: Hollås, Hanne, et al.
Publicado: (2022)

Decoding the mechanisms of allostery
por: Khan, Saif, et al.
Publicado: (2023)

Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
por: Wang, Xudong, et al.
Publicado: (2023)

The Role of Backbone Hydrogen Bonds in the Transition State for Protein Folding of a PDZ Domain
por: Pedersen, Søren W., et al.
Publicado: (2014)

Virus assembly, allostery and antivirals
por: Zlotnick, Adam, et al.
Publicado: (2011)

Convergent allostery in ribonucleotide reductase
por: Thomas, William C., et al.
Publicado: (2019)

Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle
por: McShan, Andrew C., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_kg0j3vqt1r9s9nundfb0aa230n