Targeting E-selectin to Tackle Cancer Using Uproleselan

SIMPLE SUMMARY: This review focuses on eradicating cancer by targeting a surface protein expressed on the endothelium—E-selectin—with a novel drug, uproleselan (GMI-1271). Blocking E-selectin in the tumor microenvironment acts on multiple levels; uproleselan was shown (i) to inhibit cancer cell teth...

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Detalles Bibliográficos
Autores principales: Muz, Barbara, Abdelghafer, Anas, Markovic, Matea, Yavner, Jessica, Melam, Anupama, Salama, Noha Nabil, Azab, Abdel Kareem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831123/
https://www.ncbi.nlm.nih.gov/pubmed/33477563
http://dx.doi.org/10.3390/cancers13020335

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831123/
https://www.ncbi.nlm.nih.gov/pubmed/33477563
http://dx.doi.org/10.3390/cancers13020335

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