Improved Safety and Anti-Glioblastoma Efficacy of CAT3-Encapsulated SMEDDS through Metabolism Modification

13a-(S)-3-pivaloyloxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine (CAT3) is a novel oral anti-glioma pro-drug with a potent anti-tumor effect against temozolomide-resistant glioma. 13a(S)-3-hydroxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine (PF403) is the active in vivo lipase degradation metab...

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Detalles Bibliográficos
Autores principales: Wang, Hongliang, Li, Lin, Ye, Jun, Dong, Wujun, Zhang, Xing, Xu, You, Hu, Jinping, Wang, Rubing, Xia, Xuejun, Yang, Yanfang, Jin, Dujia, Wang, Renyun, Song, Zhihui, Gao, Lili, Liu, Yuling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831126/
https://www.ncbi.nlm.nih.gov/pubmed/33477555
http://dx.doi.org/10.3390/molecules26020484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831126/
https://www.ncbi.nlm.nih.gov/pubmed/33477555
http://dx.doi.org/10.3390/molecules26020484

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