Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks

N-cadherin is a homophilic cell adhesion molecule that stabilizes excitatory synapses, by connecting pre- and post-synaptic termini. Upon NMDA receptor (NMDAR) activation by glutamate, membrane-proximal domains of N-cadherin are cleaved serially by a-disintegrin-and-metalloprotease 10 (ADAM10) and t...

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Detalles Bibliográficos
Autores principales: Asada-Utsugi, M., Uemura, K., Kubota, M., Noda, Y., Tashiro, Y., Uemura, T. M., Yamakado, H., Urushitani, M., Takahashi, R., Hattori, S., Miyakawa, T., Ageta-Ishihara, N., Kobayashi, K., Kinoshita, M., Kinoshita, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831172/
https://www.ncbi.nlm.nih.gov/pubmed/33494786
http://dx.doi.org/10.1186/s13041-021-00738-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831172/
https://www.ncbi.nlm.nih.gov/pubmed/33494786
http://dx.doi.org/10.1186/s13041-021-00738-1

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