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Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

BACKGROUND: Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with sepsis develop acute kidney injury (AKI), which is associated with a poor clinical outcome. The pathophysiology of sepsis-associated...

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Detalles Bibliográficos
Autores principales: van der Slikke, Elisabeth C., Star, Bastiaan S., van Meurs, Matijs, Henning, Robert H., Moser, Jill, Bouma, Hjalmar R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831178/
https://www.ncbi.nlm.nih.gov/pubmed/33494815
http://dx.doi.org/10.1186/s13054-020-03424-1