Functional Inactivation of Drosophila GCK Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2

Maturity-onset diabetes of the young (MODY) type 2 is caused by heterozygous inactivating mutations in the gene encoding glucokinase (GCK), a pivotal enzyme for glucose homeostasis. In the pancreas GCK regulates insulin secretion, while in the liver it promotes glucose utilization and storage. We sh...

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Detalles Bibliográficos
Autores principales: Mascolo, Elisa, Liguori, Francesco, Stufera Mecarelli, Lorenzo, Amoroso, Noemi, Merigliano, Chiara, Amadio, Susanna, Volonté, Cinzia, Contestabile, Roberto, Tramonti, Angela, Vernì, Fiammetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831483/
https://www.ncbi.nlm.nih.gov/pubmed/33477627
http://dx.doi.org/10.3390/ijms22020918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831483/
https://www.ncbi.nlm.nih.gov/pubmed/33477627
http://dx.doi.org/10.3390/ijms22020918

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