Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator

Cytosolic 5′-nucleotidase II (NT5C2) is a highly regulated enzyme involved in the maintenance of intracellular purine and the pyrimidine compound pool. It dephosphorylates mainly IMP and GMP but is also active on AMP. This enzyme is highly expressed in tumors, and its activity correlates with a high...

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Detalles Bibliográficos
Autores principales: Pesi, Rossana, Allegrini, Simone, Balestri, Francesco, Garcia-Gil, Mercedes, Cividini, Federico, Colombaioni, Laura, Jordheim, Lars Petter, Camici, Marcella, Tozzi, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831490/
https://www.ncbi.nlm.nih.gov/pubmed/33477638
http://dx.doi.org/10.3390/cells10010182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831490/
https://www.ncbi.nlm.nih.gov/pubmed/33477638
http://dx.doi.org/10.3390/cells10010182

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