Molecular Basis of NDT-Mediated Activation of Nucleoside-Based Prodrugs and Application in Suicide Gene Therapy

Herein we report the first proof for the application of type II 2′-deoxyribosyltransferase from Lactobacillus delbrueckii (LdNDT) in suicide gene therapy for cancer treatment. To this end, we first confirm the hydrolytic ability of LdNDT over the nucleoside-based prodrugs 2′-deoxy-5-fluorouridine (d...

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Detalles Bibliográficos
Autores principales: Acosta, Javier, Pérez, Elena, Sánchez-Murcia, Pedro A., Fillat, Cristina, Fernández-Lucas, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831932/
https://www.ncbi.nlm.nih.gov/pubmed/33477716
http://dx.doi.org/10.3390/biom11010120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7831932/
https://www.ncbi.nlm.nih.gov/pubmed/33477716
http://dx.doi.org/10.3390/biom11010120

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