Cargando…

Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China

Pyrazinamide (PZA) is widely used to treat drug-sensitive or multidrug resistance tuberculosis. However, conventional PZA susceptibility tests of clinical isolates are rather difficult because of the requirement of acid pH. Since resistance to pyrazinamide is primary mediated by mutation of pncA, an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Kun, Yang, Zhongping, Gu, Jing, Luo, Ming, Deng, Jiaoyu, Chen, Yaokai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832174/ https://www.ncbi.nlm.nih.gov/pubmed/33505367 http://dx.doi.org/10.3389/fmicb.2020.594171

Ejemplares similares

pncA mutations in clinical Mycobacterium tuberculosis isolates from Korea
por: Park, Soon Kew, et al.
Publicado: (2001)

Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea.
por: Lee, K. W., et al.
Publicado: (2001)

Novel Mutations in pncA Gene of Pyrazinamide Resistant Clinical Isolates of Mycobacterium tuberculosis
por: Kahbazi, Manijeh, et al.
Publicado: (2018)

pncA Mutations in the Specimens from Extrapulmonary Tuberculosis
por: Lee, Jaechun, et al.
Publicado: (2012)

Pyrazinamide Resistance and pncA Mutation Profiles in Multidrug Resistant Mycobacterium Tuberculosis
por: Shi, Dawei, et al.
Publicado: (2022)

Characteristics of pncA mutations in multidrug-resistant tuberculosis in Taiwan
por: Chiu, Yu-Chi, et al.
Publicado: (2011)

Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan
por: khan, Muhammad Tahir, et al.
Publicado: (2019)

Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance
por: Shrestha, Dipti, et al.
Publicado: (2022)

Pyrazinamide Susceptibility and pncA Mutation Profiles of Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Patients in Bangladesh
por: Rahman, Arfatur, et al.
Publicado: (2017)

Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis
por: Baddam, Ramani, et al.
Publicado: (2018)

Structure guided prediction of Pyrazinamide resistance mutations in pncA
por: Karmakar, Malancha, et al.
Publicado: (2020)

Pyrazinamide resistance of novel mutations in pncA and their dynamic behavior
por: Ali, Arif, et al.
Publicado: (2020)

High prevalence of phenotypic pyrazinamide resistance and its association with pncA gene mutations in Mycobacterium tuberculosis isolates from Uganda
por: Naluyange, Resty, et al.
Publicado: (2020)

Resistance To First-Line Antituberculosis Drugs And Prevalence Of pncA Mutations In Clinical Isolates Of Mycobacterium tuberculosis From Zunyi, Guizhou Province Of China
por: Cao, Zhimin, et al.
Publicado: (2019)

Author Correction: Analysis of mutations in pncA reveals non-overlapping patterns among various lineages of Mycobacterium tuberculosis
por: Baddam, Ramani, et al.
Publicado: (2018)

A computational perspective on the dynamic behaviour of recurrent drug resistance mutations in the pncA gene from Mycobacterium tuberculosis
por: Khan, Taimoor, et al.
Publicado: (2021)

pncA Large Deletion is the Characteristic of Pyrazinamide-Resistant Mycobacterium tuberculosis belonging to the East Asian Lineage
por: Kim, Na Yung, et al.
Publicado: (2023)

pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
por: Allana, Salim, et al.
Publicado: (2017)

1696 Total-deletion mutation of pncA as a new mechanism of pyrazinamide resistance in Mycobacterium tuberculosis - The first report from Japan
por: Kobayashi, Masahiro, et al.
Publicado: (2014)

Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia
por: Sengstake, Sarah, et al.
Publicado: (2017)

Insights Into Mutations Induced Conformational Changes and Rearrangement of Fe(2+) Ion in pncA Gene of Mycobacterium tuberculosis to Decipher the Mechanism of Resistance to Pyrazinamide
por: Nangraj, Asma Sindhoo, et al.
Publicado: (2021)

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide
por: Yadon, Adam N., et al.
Publicado: (2017)

Gibbs Free Energy Calculation of Mutation in PncA and RpsA Associated With Pyrazinamide Resistance
por: Khan, Muhammad Tahir, et al.
Publicado: (2020)

Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection
por: Dudley, Matthew Z., et al.
Publicado: (2016)

Structural Dynamics Behind Clinical Mutants of PncA-Asp12Ala, Pro54Leu, and His57Pro of Mycobacterium tuberculosis Associated With Pyrazinamide Resistance
por: Mehmood, Aamir, et al.
Publicado: (2019)

Mutations of folC cause increased susceptibility to sulfamethoxazole in Mycobacterium tuberculosis
por: Wang, Ruiqi, et al.
Publicado: (2021)

Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid
por: Feng, Shengyu, et al.
Publicado: (2023)

Activity of Pyrazinamide against Mycobacterium tuberculosis at Neutral pH in PZA-S1 Minimal Medium
por: Shi, Wanliang
Publicado: (2021)

Rapid Pyrazinamide Drug Susceptibility Testing using a Closed-Tube PCR Assay of the Entire pncA gene
por: Whitfield, Michael G., et al.
Publicado: (2020)

PncAgene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis
por: Untiveros, Katherine Lozano, et al.
Publicado: (2014)

Investigation of bedaquiline resistance and genetic mutations in multi-drug resistant Mycobacterium tuberculosis clinical isolates in Chongqing, China
por: Hu, Yan, et al.
Publicado: (2023)

Direct Determination of Pyrazinamide (PZA) Susceptibility by Sputum Microscopic Observation Drug Susceptibility (MODS) Culture at Neutral pH: the MODS-PZA Assay
por: Alcántara, Roberto, et al.
Publicado: (2020)

Evaluation of PCR pncA-restriction fragment length polymorphism and PCR amplification of genomic regions of difference for the identification of M. bovis strains in lymph nodes cultures
por: Bouzouita, Imen, et al.
Publicado: (2021)

Ability of the MeltPro MTB/PZA Assay to Detect Susceptibility to Pyrazinamide in Rifampin-Resistant Tuberculosis Patients
por: Li, Rong, et al.
Publicado: (2023)

Independent Risk Factors for Deaths due to AIDS in Chongqing, China: Does Age Matter?
por: Zhou, Yihong, et al.
Publicado: (2021)

Molecular Characterization of Prothionamide-Resistant Mycobacterium tuberculosis Isolates in Southern China
por: Tan, Yaoju, et al.
Publicado: (2017)

Molecular characterization of para-aminosalicylic acid resistant Mycobacterium tuberculosis clinical isolates in southwestern China
por: Luo, Ming, et al.
Publicado: (2019)

Interplay between Mutations and Efflux in Drug Resistant Clinical Isolates of Mycobacterium tuberculosis
por: Machado, Diana, et al.
Publicado: (2017)

The impact of inclusion, dose and duration of pyrazinamide (PZA) on efficacy and safety outcomes in tuberculosis: systematic review and meta-analysis protocol
por: Millard, James D., et al.
Publicado: (2019)

Genomic characteristics of Mycobacterium tuberculosis isolates of cutaneous tuberculosis
por: Mei, You-Ming, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lce6g2933is7j4ktaq1iaq9jsp