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Enhancing the Physiochemical Properties of Puerarin via L-Proline Co-Crystallization: Synthesis, Characterization, and Dissolution Studies of Two Phases of Pharmaceutical Co-Crystals
Puerarin (PUE) is a Chinese traditional medicine known to enhance glucose uptake into the insulin cells to downregulate the blood glucose levels in the treatment of type II diabetes. Nevertheless, the bioavailability of pristine PUE is limited due to its poor solubility and low intestinal permeabili...
Autores principales: | Inam, Muhammad, Liu, Lu, Wang, Jian-Wei, Yu, Ka-Xi, Phan, Chi-Uyen, Shen, Jie, Zhang, Wen-Hua, Tang, Guping, Hu, Xiurong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832312/ https://www.ncbi.nlm.nih.gov/pubmed/33477727 http://dx.doi.org/10.3390/ijms22020928 |
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