Cargando…

ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 susceptibility or severity, and the role of direct viral infection in brain cells remains obscure. We tested the neurotropism o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Cheng, Zhang, Mingzi, Garcia, Gustavo, Tian, E., Cui, Qi, Chen, Xianwei, Sun, Guihua, Wang, Jinhui, Arumugaswami, Vaithilingaraja, Shi, Yanhong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2021
Materias:	Short Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832490/ https://www.ncbi.nlm.nih.gov/pubmed/33450186 http://dx.doi.org/10.1016/j.stem.2020.12.018

Ejemplares similares

Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses
por: Sun, Guihua, et al.
Publicado: (2021)

Compound screen identifies the small molecule Q34 as an inhibitor of SARS-CoV-2 infection
por: Cui, Qi, et al.
Publicado: (2021)

The Apolipoprotein E neutralizing antibody inhibits SARS‐CoV‐2 infection by blocking cellular entry of lipoviral particles
por: Cui, Qi, et al.
Publicado: (2023)

Cold atmospheric plasma for SARS-CoV-2 inactivation
por: Chen, Zhitong, et al.
Publicado: (2020)

Structure-based design of antisense oligonucleotides that inhibit SARS-CoV-2 replication
por: Li, Yan, et al.
Publicado: (2021)

Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
por: Sharma, Arun, et al.
Publicado: (2020)

ORAI1 establishes resistance to SARS-CoV-2 infection by regulating tonic type I interferon signaling
por: Wu, Beibei, et al.
Publicado: (2021)

Emerging neurotropic features of SARS-CoV-2
por: Zhan, Wen-Rong, et al.
Publicado: (2021)

Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells
por: Shaharuddin, Syairah Hanan, et al.
Publicado: (2021)

Neurotropism of SARS-CoV 2: Mechanisms and manifestations
por: Conde Cardona, Giancarlos, et al.
Publicado: (2020)

The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2
por: Bauer, Lisa, et al.
Publicado: (2022)

Understanding the neurotropic characteristics of SARS-CoV-2: from neurological manifestations of COVID-19 to potential neurotropic mechanisms
por: Zhou, Zhiqiang, et al.
Publicado: (2020)

ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition
por: Waldie, Sarah, et al.
Publicado: (2021)

Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium
por: Jacob, Fadi, et al.
Publicado: (2020)

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention
por: Li, Yan-Ruide, et al.
Publicado: (2022)

Cell receptor-independent infection by a neurotropic murine coronavirus
por: Gallagher, Thomas M., et al.
Publicado: (1992)

Lag-time in Alzheimer’s disease patients: a potential plasmatic oxidative stress marker associated with ApoE4 isoform
por: Massaccesi, Luca, et al.
Publicado: (2019)

Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids
por: Ramani, Anand, et al.
Publicado: (2021)

In Silico Genome Analysis Reveals the Evolution and Potential Impact of SARS-CoV-2 Omicron Structural Changes on Host Immune Evasion and Antiviral Therapeutics
por: Chauhan, Dhruv, et al.
Publicado: (2022)

SARS-CoV-2 and its beta variant of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response
por: Singh, Sneha, et al.
Publicado: (2022)

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
por: Cheng, Mary Hongying, et al.
Publicado: (2020)

A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro
por: Cheng, Mary Hongying, et al.
Publicado: (2021)

Return of the Neurotropic Enteroviruses: Co-Opting Cellular Pathways for Infection
por: Peters, Christine E., et al.
Publicado: (2021)

Neurotropism of SARS-CoV-2 and its neuropathological alterations: Similarities with other coronaviruses
por: Hu, Jingman, et al.
Publicado: (2020)

The continuum of SARS-CoV-2's neurotropism and the potential for immune-mediated neuronal injury
por: Vavougios, George D.
Publicado: (2020)

Neurotropism of Salvarsan
Publicado: (1911)

ApoE isoform-dependent changes in hippocampal synaptic function
por: Korwek, Kimberly M, et al.
Publicado: (2009)

ApoE isoforms differentially regulates cleavage and secretion of BDNF
por: Sen, Abhik, et al.
Publicado: (2017)

COVID-19 Anosmia: High Prevalence, Plural Neuropathogenic Mechanisms, and Scarce Neurotropism of SARS-CoV-2?
por: Liang, Fengyi, et al.
Publicado: (2021)

Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors
por: Xu, Guangxue, et al.
Publicado: (2022)

Draft Genome Sequence of the Earthworm Eudrilus eugeniae
por: Arumugaperumal, Arun, et al.
Publicado: (2022)

Neurotropic Coronavirus Infections
por: Perlman, Stanley, et al.
Publicado: (2016)

Neurotropic Astroviruses in Animals
por: Wildi, Nicole, et al.
Publicado: (2021)

Neurotropism of SARS-CoV-2 and neurological diseases of the central nervous system in COVID-19 patients
por: Veleri, Shobi
Publicado: (2021)

Neuroinvasion and Neurotropism by SARS-CoV-2 Variants in the K18-hACE2 Mouse
por: Seehusen, Frauke, et al.
Publicado: (2022)

A neurotropic herpesvirus infecting the gastropod, abalone, shares ancestry with oyster herpesvirus and a herpesvirus associated with the amphioxus genome
por: Savin, Keith W, et al.
Publicado: (2010)

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response
por: Garcia, Gustavo, et al.
Publicado: (2022)

Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients
por: Yachou, Yassine, et al.
Publicado: (2020)

Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells
por: Suhane, Sonal, et al.
Publicado: (2013)

Hippo signaling pathway activation during SARS-CoV-2 infection contributes to host antiviral response
por: Garcia, Gustavo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5fdoutjsgle1inmc8rafifs7ha