Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors?
BACKGROUND: This study examined the possible association between the prognostic nutritional index (PNI) and in-hospital mortality rates in cases with a high cardiovascular risk burden and hospitalized with the diagnosis of coronavirus disease 2019 (COVID-19). MATERIAL AND METHODS: This retrospective...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832700/ https://www.ncbi.nlm.nih.gov/pubmed/33482433 http://dx.doi.org/10.1016/j.hrtlng.2021.01.006 |
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author | Çınar, Tufan Hayıroğlu, Mert İlker Çiçek, Vedat Kılıç, Şahhan Asal, Süha Yavuz, Samet Selçuk, Murat Yalçınkaya, Emre Keser, Nurgül Orhan, Ahmet Lütfullah |
author_facet | Çınar, Tufan Hayıroğlu, Mert İlker Çiçek, Vedat Kılıç, Şahhan Asal, Süha Yavuz, Samet Selçuk, Murat Yalçınkaya, Emre Keser, Nurgül Orhan, Ahmet Lütfullah |
author_sort | Çınar, Tufan |
collection | PubMed |
description | BACKGROUND: This study examined the possible association between the prognostic nutritional index (PNI) and in-hospital mortality rates in cases with a high cardiovascular risk burden and hospitalized with the diagnosis of coronavirus disease 2019 (COVID-19). MATERIAL AND METHODS: This retrospective and cross-sectional study included 294 COVID-19 patients hospitalized in a tertiary referral pandemic center. The study cohort was grouped into tertiles based on the initial PNI values as T1, T2, and T3. The PNI was calculated for each case and the prognostic value of this index was compared to CURB-65 and 4C mortality risk scores in predicting in-hospital mortality. RESULTS: Patients stratified into the T1 tertile had a lower lymphocyte count, serum albumin level, and PNI values. In a multivariate analysis, the PNI (OR: 0.688,%95CI: 0.586–0.808, p < 0.001) was an independent predictor for all-cause in-hospital death. After adjusting for confounding independent parameters, patients included in the T1 tertile were found to have 11.2 times higher rates of in-hospital mortality compared to the T3 group, which was presumed as the reference group. In addition, we found that the area under curve (AUC) value of PNI was significantly elevated than that of serum albumin level and total lymphocyte counts alone. [(AUC):0.79 vs AUC:0.75 vs AUC:0.69; respectively). CONCLUSION: This study demonstrated that the PNI is independently related with in-hospital mortality in patient with COVID-19 and cardiovascular risk factors. The power of the PNI was also validated using well-accepted risk scores of COVID-19 such as CURB-65 and 4C mortality risk scores. |
format | Online Article Text |
id | pubmed-7832700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78327002021-01-26 Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? Çınar, Tufan Hayıroğlu, Mert İlker Çiçek, Vedat Kılıç, Şahhan Asal, Süha Yavuz, Samet Selçuk, Murat Yalçınkaya, Emre Keser, Nurgül Orhan, Ahmet Lütfullah Heart Lung Article BACKGROUND: This study examined the possible association between the prognostic nutritional index (PNI) and in-hospital mortality rates in cases with a high cardiovascular risk burden and hospitalized with the diagnosis of coronavirus disease 2019 (COVID-19). MATERIAL AND METHODS: This retrospective and cross-sectional study included 294 COVID-19 patients hospitalized in a tertiary referral pandemic center. The study cohort was grouped into tertiles based on the initial PNI values as T1, T2, and T3. The PNI was calculated for each case and the prognostic value of this index was compared to CURB-65 and 4C mortality risk scores in predicting in-hospital mortality. RESULTS: Patients stratified into the T1 tertile had a lower lymphocyte count, serum albumin level, and PNI values. In a multivariate analysis, the PNI (OR: 0.688,%95CI: 0.586–0.808, p < 0.001) was an independent predictor for all-cause in-hospital death. After adjusting for confounding independent parameters, patients included in the T1 tertile were found to have 11.2 times higher rates of in-hospital mortality compared to the T3 group, which was presumed as the reference group. In addition, we found that the area under curve (AUC) value of PNI was significantly elevated than that of serum albumin level and total lymphocyte counts alone. [(AUC):0.79 vs AUC:0.75 vs AUC:0.69; respectively). CONCLUSION: This study demonstrated that the PNI is independently related with in-hospital mortality in patient with COVID-19 and cardiovascular risk factors. The power of the PNI was also validated using well-accepted risk scores of COVID-19 such as CURB-65 and 4C mortality risk scores. Elsevier Inc. 2021 2021-01-13 /pmc/articles/PMC7832700/ /pubmed/33482433 http://dx.doi.org/10.1016/j.hrtlng.2021.01.006 Text en © 2021 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Çınar, Tufan Hayıroğlu, Mert İlker Çiçek, Vedat Kılıç, Şahhan Asal, Süha Yavuz, Samet Selçuk, Murat Yalçınkaya, Emre Keser, Nurgül Orhan, Ahmet Lütfullah Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? |
title | Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? |
title_full | Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? |
title_fullStr | Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? |
title_full_unstemmed | Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? |
title_short | Is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in COVID-19 patients with cardiovascular risk factors? |
title_sort | is prognostic nutritional index a predictive marker for estimating all-cause in-hospital mortality in covid-19 patients with cardiovascular risk factors? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832700/ https://www.ncbi.nlm.nih.gov/pubmed/33482433 http://dx.doi.org/10.1016/j.hrtlng.2021.01.006 |
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