Aggregated LDL turn human macrophages into foam cells and induce mitochondrial dysfunction without triggering oxidative or endoplasmic reticulum stress

Uptake of modified lipoproteins by macrophages turns them into foam cells, the hallmark of the atherosclerotic plaque. The initiation and progression of atherosclerosis have been associated with mitochondrial dysfunction. It is known that aggregated low-density lipoproteins (agLDL) induce massive ch...

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Detalles Bibliográficos
Autores principales: Sanda, Gabriela M., Stancu, Camelia S., Deleanu, Mariana, Toma, Laura, Niculescu, Loredan S., Sima, Anca V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833132/
https://www.ncbi.nlm.nih.gov/pubmed/33493198
http://dx.doi.org/10.1371/journal.pone.0245797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833132/
https://www.ncbi.nlm.nih.gov/pubmed/33493198
http://dx.doi.org/10.1371/journal.pone.0245797

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