Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA

The causative virus of the COVID-19 pandemic, SARS-CoV-2, uses its nonstructural protein 1 (Nsp1) to suppress cellular, but not viral, protein synthesis through yet unknown mechanisms. We show here that among all viral proteins, Nsp1 has the largest impact on host viability in the cells of human lun...

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Detalles Bibliográficos
Autores principales: Yuan, Shuai, Peng, Lei, Park, Jonathan J., Hu, Yingxia, Devarkar, Swapnil C., Dong, Matthew B., Shen, Qi, Wu, Shenping, Chen, Sidi, Lomakin, Ivan B., Xiong, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833686/
https://www.ncbi.nlm.nih.gov/pubmed/33188728
http://dx.doi.org/10.1016/j.molcel.2020.10.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7833686/
https://www.ncbi.nlm.nih.gov/pubmed/33188728
http://dx.doi.org/10.1016/j.molcel.2020.10.034

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