Cargando…

SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhan, Yu-Ting, Li, Lei, Zeng, Ting-Ting, Zhou, Ning-Ning, Guan, Xin-Yuan, Li, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7834993/ https://www.ncbi.nlm.nih.gov/pubmed/33289700 http://dx.doi.org/10.18632/aging.202164

Ejemplares similares

Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis
por: Alam, Sabrina Shameen, et al.
Publicado: (2022)

SNRPB promotes cell cycle progression in thyroid carcinoma via inhibiting p53
por: Deng, Yan, et al.
Publicado: (2022)

Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma
por: Correa, Bruna R., et al.
Publicado: (2016)

The oncogenic role of SNRPB in human tumors: A pan-cancer analysis
por: Wu, Juan, et al.
Publicado: (2022)

The Core Splicing Factors EFTUD2, SNRPB and TXNL4A Are Essential for Neural Crest and Craniofacial Development
por: Park, Byung-Yong, et al.
Publicado: (2022)

TROAP switches DYRK1 activity to drive hepatocellular carcinoma progression
por: Li, Lei, et al.
Publicado: (2021)

SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26
por: Liu, Nianli, et al.
Publicado: (2019)

lncRNA RUNDC3A-AS1 Regulates Proliferation and Apoptosis of Thyroid Cancer Cells via the miR-151b/SNRPB Axis
por: Deng, Yan, et al.
Publicado: (2022)

Disrupted auto-regulation of the spliceosomal gene SNRPB causes cerebro–costo–mandibular syndrome
por: Lynch, Danielle C., et al.
Publicado: (2014)

HN1L/AP-2γ/PLK1 signaling drives tumor progression and chemotherapy resistance in esophageal squamous cell carcinoma
por: Zeng, Ting-Ting, et al.
Publicado: (2022)

Long non-coding RNA CCAT2 functions as an oncogene in hepatocellular carcinoma, regulating cellular proliferation, migration and apoptosis
por: ZHOU, NING, et al.
Publicado: (2016)

An Alternatively Spliced Variant of METTL3 Mediates Tumor Suppression in Hepatocellular Carcinoma
por: Xu, Rui-Yao, et al.
Publicado: (2022)

The Progress and Prospects of Putative Biomarkers for Liver Cancer Stem Cells in Hepatocellular Carcinoma
por: Xiang, Yan, et al.
Publicado: (2016)

Cisd2 haploinsufficiency: A driving force for hepatocellular carcinoma
por: Shen, Zhao-Qing, et al.
Publicado: (2018)

FOXM1-Mediated LINC-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular Carcinoma
por: Zhi, Yingru, et al.
Publicado: (2019)

SERPINA11 Inhibits Metastasis in Hepatocellular Carcinoma by Suppressing MEK/ERK Signaling Pathway
por: Song, Ye, et al.
Publicado: (2021)

RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway
por: Han, Hexu, et al.
Publicado: (2021)

Alternative Splicing in Hepatocellular Carcinoma
por: Lee, Seung Eun, et al.
Publicado: (2020)

Cleavage and Polyadenylation Specific Factor 1 Promotes Tumor Progression via Alternative Polyadenylation and Splicing in Hepatocellular Carcinoma
por: Chen, Shi-lu, et al.
Publicado: (2021)

Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma
por: Zhang, Yong-Fa, et al.
Publicado: (2021)

LncRNA RHPN1-AS1 Promotes Cell Proliferation, Migration and Invasion Through Targeting miR-7-5p and Activating PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma
por: Song, Xue-zhen, et al.
Publicado: (2020)

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway
por: Zheng, Yin-Li, et al.
Publicado: (2019)

A human-specific switch of alternatively spliced AFMID isoforms contributes to TP53 mutations and tumor recurrence in hepatocellular carcinoma
por: Lin, Kuan-Ting, et al.
Publicado: (2018)

Methylation mediated Gadd45β enhanced the chemosensitivity of hepatocellular carcinoma by inhibiting the stemness of liver cancer cells
por: Hou, Xiao-Juan, et al.
Publicado: (2017)

Alternative splicing events are prognostic in hepatocellular carcinoma
por: Chen, Qi-Feng, et al.
Publicado: (2019)

Knockdown of Golgi phosphoprotein 2 inhibits hepatocellular carcinoma cell proliferation and motility
por: Liu, Yiming, et al.
Publicado: (2016)

Stemness and chemotherapeutic drug resistance induced by EIF5A2 overexpression in esophageal squamous cell carcinoma
por: Yang, Hong, et al.
Publicado: (2015)

Silencing GTSE-1 expression inhibits proliferation and invasion of hepatocellular carcinoma cells
por: Guo, Lei, et al.
Publicado: (2016)

Comprehensive analysis of RNA-binding protein SRSF2-dependent alternative splicing signature in malignant proliferation of colorectal carcinoma
por: Liu, Weizhen, et al.
Publicado: (2023)

Profiles of prognostic alternative splicing signature in hepatocellular carcinoma
por: Wu, Fangming, et al.
Publicado: (2020)

Spontaneous Immune-Mediated Regression of Hepatocellular Carcinoma With High Tumor Mutational Burden
por: Franses, Joseph W., et al.
Publicado: (2021)

Splicing factor PRPF6 upregulates oncogenic androgen receptor signaling pathway in hepatocellular carcinoma
por: Song, Huijuan, et al.
Publicado: (2020)

FAM46C is critical for the anti-proliferation and pro-apoptotic effects of norcantharidin in hepatocellular carcinoma cells
por: Zhang, Qiao-Yan, et al.
Publicado: (2017)

LncRNA ANCR Suppresses the Progression of Hepatocellular Carcinoma Through the Inhibition of Wnt/β-Catenin Signaling Pathway
por: Song, Xue-zhen, et al.
Publicado: (2020)

Cancer Stem Cell Functions in Hepatocellular Carcinoma and Comprehensive Therapeutic Strategies
por: Liu, Yu-Chin, et al.
Publicado: (2020)

Biomarkers for hepatocellular carcinoma based on body fluids and feces
por: Guan, Ming-Cheng, et al.
Publicado: (2021)

CAMSAP2-mediated noncentrosomal microtubule acetylation drives hepatocellular carcinoma metastasis
por: Li, Dongxiao, et al.
Publicado: (2020)

Integrative Analysis Identifies Cell-Type-Specific Genes Within Tumor Microenvironment as Prognostic Indicators in Hepatocellular Carcinoma
por: Huang, Zi-Li, et al.
Publicado: (2022)

Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461
por: Li, Guihong, et al.
Publicado: (2018)

CTNNA3 is a tumor suppressor in hepatocellular carcinomas and is inhibited by miR-425
por: He, Bing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_smc107j5v02gthkftd44m8avkf